Laboratory practice guidelines for detecting and reporting JAK2 and MPL mutations in myeloproliferative neoplasms: a report of the Association for Molecular Pathology.
Publication/Presentation Date
11-1-2013
Abstract
Recurrent mutations in JAK2 and MPL genes are genetic hallmarks of BCR-ABL1-negative myeloproliferative neoplasms. Detection of JAK2 and MPL mutations has been incorporated into routine diagnostic algorithms for these diseases. This Special Article summarizes results from a nationwide laboratory survey of JAK2 and MPL mutation analysis. Based on the current practice pattern and the literature, this Special Article provides recommendations and guidelines for laboratory practice for detection of mutations in the JAK2 and MPL genes, including clinical manifestations for prompting the mutation analysis, current and recommended methodologies for testing the mutations, and standardization for reporting the test results. This Special Article also points to future directions for genomic testing in BCR-ABL1-negative myeloproliferative neoplasms.
Volume
15
Issue
6
First Page
733
Last Page
744
ISSN
1943-7811
Published In/Presented At
Gong, J. Z., Cook, J. R., Greiner, T. C., Hedvat, C., Hill, C. E., Lim, M. S., Longtine, J. A., Sabath, D., Wang, Y. L., & Association for Molecular Pathology (2013). Laboratory practice guidelines for detecting and reporting JAK2 and MPL mutations in myeloproliferative neoplasms: a report of the Association for Molecular Pathology. The Journal of molecular diagnostics : JMD, 15(6), 733–744. https://doi.org/10.1016/j.jmoldx.2013.07.002
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
23978506
Department(s)
Administration and Leadership
Document Type
Article