Primary central nervous system plasmablastic lymphoma in an HIV-positive patient.
Publication/Presentation Date
3-14-2019
Abstract
Plasmablastic lymphoma (PBL) is a rare subtype of diffuse large B-cell lymphoma, highly associated with HIV and Epstein-Barr virus (EBV) infections. It commonly presents in extranodal sites, often an oral mass, but reports of primary central nervous system PBL (PCNSPBL) are exceedingly rare. Here, we report on a 33-year-old man with newly diagnosed HIV infection who presented with acute-onset unilateral visual disturbance and was found to have biopsy-proven PCNSPBL. The neoplastic cells displayed a plasmacytoid appearance, with the expression of CD38 and CD138, and were positive for EBV by in situ hybridisation for EBV-encoded RNA. Systemic workup revealed the presence of Kaposi sarcoma, but no evidence of lymphoma. He is currently being treated with high-dose methotrexate, as well as antiretroviral therapy for his HIV infection, and has achieved a complete response.
Volume
12
Issue
3
ISSN
1757-790X
Published In/Presented At
Rhoades, R., Gong, J., Palmisiano, N., & Alpdogan, O. (2019). Primary central nervous system plasmablastic lymphoma in an HIV-positive patient. BMJ case reports, 12(3), e226755. https://doi.org/10.1136/bcr-2018-226755
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
30872336
Department(s)
Administration and Leadership
Document Type
Article