Comprehensive peripheral blood immunoprofiling reveals five immunotypes with immunotherapy response characteristics in patients with cancer.
Publication/Presentation Date
5-13-2024
Abstract
The lack of comprehensive diagnostics and consensus analytical models for evaluating the status of a patient's immune system has hindered a wider adoption of immunoprofiling for treatment monitoring and response prediction in cancer patients. To address this unmet need, we developed an immunoprofiling platform that uses multiparameter flow cytometry to characterize immune cell heterogeneity in the peripheral blood of healthy donors and patients with advanced cancers. Using unsupervised clustering, we identified five immunotypes with unique distributions of different cell types and gene expression profiles. An independent analysis of 17,800 open-source transcriptomes with the same approach corroborated these findings. Continuous immunotype-based signature scores were developed to correlate systemic immunity with patient responses to different cancer treatments, including immunotherapy, prognostically and predictively. Our approach and findings illustrate the potential utility of a simple blood test as a flexible tool for stratifying cancer patients into therapy response groups based on systemic immunoprofiling.
Volume
42
Issue
5
First Page
759
Last Page
779
ISSN
1878-3686
Published In/Presented At
Dyikanov, D., Zaitsev, A., Vasileva, T., Wang, I., Sokolov, A. A., Bolshakov, E. S., Frank, A., Turova, P., Golubeva, O., Gantseva, A., Kamysheva, A., Shpudeiko, P., Krauz, I., Abdou, M., Chasse, M., Conroy, T., Merriam, N. R., Alesse, J. E., English, N., Shpak, B., … Goldberg, M. F. (2024). Comprehensive peripheral blood immunoprofiling reveals five immunotypes with immunotherapy response characteristics in patients with cancer. Cancer cell, 42(5), 759–779.e12. https://doi.org/10.1016/j.ccell.2024.04.008
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
38744245
Department(s)
Administration and Leadership
Document Type
Article