A preliminary report of percutaneous craniofacial osteoplasty in a rat calvarium.
Publication/Presentation Date
7-1-2014
Abstract
OBJECTIVES/HYPOTHESIS: To evaluate the potential for injectable, permanent bone augmentation by assessing the biocompatability and bioactivity of subperiosteal hydroxylapatite (Radiesse) deposition in a rat model.
STUDY DESIGN: Randomized controlled animal model.
METHODS: Fourteen adult Sprague Dawley rats were injected in the parietal skull with 0.2 ml of hydroxylapatite (10 animals) or 0.2 ml of a carrier gel control (4 animals), using a subperiosteal injection technique on the right and a subcutaneous injection technique on the left. At 1, 3, and 6 months, three rats (1 negative control, 2 variables) were sacrificed and the calvaria were harvested. At 12 months, the remaining five rats were sacrificed. After each harvest, the specimens were processed and then examined under both light and polarized microscopy for new bone growth at the injection sites.
RESULTS: The inflammatory response was limited with both hydroxylapatite and carrier injections. Injectables were still present 12 months after the injection. New bone formation was only observed when the injection was located deep to a disrupted periosteum The odds of new bone formation was 48.949 times higher (95% confidence intervals CI [2.637, 3759.961]; P=0.002) with subperiosteal hydroxylapatite injections compared to all other combinations of injection plane and injectable.
CONCLUSIONS: This preliminary report of subperiosteal hydroxylapatite (Radiesse) injection in a rat model has verified the biocompatibility of injectable hydroxylapatite at the bony interface and suggests the potential for new bone formation.
LEVEL OF EVIDENCE: N/A.
Volume
124
Issue
7
First Page
1550
Last Page
1553
ISSN
1531-4995
Published In/Presented At
Parkes, W. J., Greywoode, J., O'Hara, B. J., Heffelfinger, R. N., & Krein, H. (2014). A preliminary report of percutaneous craniofacial osteoplasty in a rat calvarium. The Laryngoscope, 124(7), 1550–1553. https://doi.org/10.1002/lary.24459
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
24122773
Department(s)
Administration and Leadership
Document Type
Article