Effect of antenatal corticosteroids on survival for neonates born at 23 weeks of gestation.
Publication/Presentation Date
4-1-2008
Abstract
OBJECTIVE: To estimate if exposure to antenatal corticosteroids was associated with decreased rate of death in neonates born at 23 weeks of gestation.
METHODS: This is a retrospective cohort study performed at three tertiary centers of neonates born at 23 weeks of gestation between 1998 and 2007. Stillbirths, voluntary terminations, or parental elected nonresuscitations were excluded. Clinical and demographic variables were examined to determine possible confounding variables. A multivariable logistic regression model was used to assess the effect of steroids on the odds of death after adjustment for these confounders.
RESULTS: The sample included 181 neonates. Of the multiple variables examined (institution, race, diagnosis, illicit drug use, antibiotics, assisted reproduction, birth weight, gender, and route of delivery), only multiple gestations were significantly associated (P
CONCLUSION: Neonates at 23 weeks of gestation whose mothers completed a course of antenatal corticosteroids had an associated 82% reduction in odds of death.
Volume
111
Issue
4
First Page
921
Last Page
926
ISSN
0029-7844
Published In/Presented At
Hayes, E. J., Paul, D. A., Stahl, G. E., Seibel-Seamon, J., Dysart, K., Leiby, B. E., Mackley, A. B., & Berghella, V. (2008). Effect of antenatal corticosteroids on survival for neonates born at 23 weeks of gestation. Obstetrics and gynecology, 111(4), 921–926. https://doi.org/10.1097/AOG.0b013e318169ce2d
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
18378752
Department(s)
Administration and Leadership
Document Type
Article