Antenatal corticosteroids for maturity of term or near term fetuses: systematic review and meta-analysis of randomized controlled trials.
Publication/Presentation Date
10-12-2016
Abstract
OBJECTIVE: To evaluate the effectiveness of antenatal corticosteroids given at ≥34 weeks' gestation.
DESIGN: Systematic review with meta-analysis.
DATA SOURCES: Electronic databases were searched from their inception to February 2016.
ELIGIBILITY CRITERIA FOR STUDY SELECTION: Randomized clinical trials comparing antenatal corticosteroids with placebo or no treatment in women with a singleton pregnancy at ≥34 weeks' gestation. Trials on antenatal steroids in women expected to deliver late preterm (34
DATA SYNTHESIS: The primary outcome was the incidence of severe respiratory distress syndrome (RDS). The summary measures were reported as relative risks or mean differences with 95% confidence intervals.
RESULTS: Six trials, including 5698 singleton pregnancies, were analyzed. Three included 3200 women at 34
CONCLUSIONS: Antenatal steroids at ≥34 weeks' gestation reduce neonatal respiratory morbidity. A single course of corticosteroids can be considered for women at risk of imminent late premature delivery 34
SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42016035234.
Volume
355
First Page
5044
Last Page
5044
ISSN
1756-1833
Published In/Presented At
Saccone, G., & Berghella, V. (2016). Antenatal corticosteroids for maturity of term or near term fetuses: systematic review and meta-analysis of randomized controlled trials. BMJ (Clinical research ed.), 355, i5044. https://doi.org/10.1136/bmj.i5044
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
27733360
Department(s)
Administration and Leadership
Document Type
Article