Predictors of Early Preterm Birth Despite Vaginal Progesterone Therapy in Singletons with Short Cervix.

Publication/Presentation Date

11-1-2020

Abstract

OBJECTIVE: This study aimed to identify the incidence of and risk factors for early preterm birth (PTB) (delivery < 34 weeks) in women without prior PTB and current short cervix (≤20 mm) prescribed vaginal progesterone.

STUDY DESIGN: Retrospective cohort study of singletons without prior PTB diagnosed with short cervix (≤20 mm) between 18

RESULTS: Among 109 patients included, 29 (27%) had a spontaneous PTB < 34 weeks. In univariate analysis, only gestational age at ultrasound, presence funneling, and mean cervical length were significantly different between those with and without early sPTB. With multiple logistic regression analysis, only gestational age at diagnosis (odds ratio [OR]: 0.66; 95% confidence interval [CI]: 0.46-0.96;

CONCLUSION: A total of 27% of patients with short cervix prescribed vaginal progesterone will have a sPTB <  34 weeks. Patients at high risk for early PTB despite vaginal progesterone therapy may be identified using gestational age and cervical length at diagnosis of short cervix. Given the narrow window for intervention after diagnosis of short cervix, this has important implications for clinical care.

Volume

37

Issue

13

First Page

1289

Last Page

1295

ISSN

1098-8785

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

32344443

Department(s)

Administration and Leadership

Document Type

Article

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