Follicular carcinoma of the thyroid with extensive clear-cell differentiation: a potential diagnostic pitfall.
Publication/Presentation Date
6-1-2000
Abstract
Clear-cell features have been recognized in several different thyroid neoplasms. A case of thyroid follicular carcinoma with extensive clear- and Hurthle-cell features is described in a 37-yr-old white female, with cytochemical and immunohistochemical analysis. The tumor of the thyroid gland, with anterior neck soft-tissue extension, displayed clear cells on fine-needle aspiration, which were negative for thyroglobulin. The surgical specimen displayed predominately clear cells (80%), and only the nonclear-cell areas stained for thyroblobulin. Proper categorization of clear-cell lesions of the thyroid and soft tissues requires a multimodality approach, involving clinical/pathological correlation, morphological analysis, and ancillary tissue studies. Immunohistochemical stains for thyroglobulin are quite definitive in making the distinction between primary clear-cell thyroid tumors vs. metastatic clear-cell tumors. Cytologists should be aware, however, that the clear-cell areas of thyroid tumors might not stain for thyroglobulin.
Volume
22
Issue
6
First Page
398
Last Page
399
ISSN
8755-1039
Published In/Presented At
Ropp, B. G., Solomides, C., Palazzo, J., & Bibbo, M. (2000). Follicular carcinoma of the thyroid with extensive clear-cell differentiation: a potential diagnostic pitfall. Diagnostic cytopathology, 22(6), 398–399. https://doi.org/10.1002/(sici)1097-0339(200006)22:6<398::aid-dc14>3.0.co;2-t
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
10820537
Department(s)
Administration and Leadership
Document Type
Article