Uterine closure techniques during cesarean delivery and placenta accreta spectrum incidence in subsequent pregnancies: A systematic review and meta-analysis.
Publication/Presentation Date
1-1-2026
Abstract
OBJECTIVE: To evaluate multiple uterine closure techniques during cesarean delivery (CD) and placenta accreta spectrum (PAS) incidence in the following pregnancy.
DESIGN: Systematic review with meta-analysis.
DATA SOURCES: Medline, Cochrane Library, EMBASE, PubMed Central, Scopus, and ClinicalTrial.gov were electronically searched from their inception to September 2025.
ELIGIBILITY CRITERIA FOR SELECTING STUDIES: We included all studies with a control population that compared different uterine closure techniques during CD-namely (1) type of suture; (2) inclusion or not of the decidua; (3) continuous versus interrupted suture; (4) locking versus non-locking suture; (5) pursed-string or not; (6) single- versus double-layer suture-with PAS incidence at the following pregnancy.
DATA SYNTHESIS: The primary outcome was PAS incidence at the following pregnancy.
RESULTS: We could not find any controlled study with follow-up data for PAS at the subsequent pregnancy in terms of type of suture utilized, inclusion or not of the decidua, or pursed-string closure at index CD. Three trials, including 1787 pregnancies, were analyzed and judged as "high quality," showing a potential association between continuous versus interrupted suture and PAS, but no difference with respect to locking versus non-locking or single- versus double-layer closures.
CONCLUSIONS: As of now, it is impossible to mandate a specific uterine closure technique during CD with the aim of reducing the incidence of PAS at the following pregnancy. Large randomized controlled trials are needed.
Volume
2
Issue
1
First Page
70244
Last Page
70244
ISSN
2997-9684
Published In/Presented At
Petrecca, A., Gomez, J., Raymond, M., Tersigni, C., & Berghella, V. (2026). Uterine closure techniques during cesarean delivery and placenta accreta spectrum incidence in subsequent pregnancies: A systematic review and meta-analysis. Pregnancy (Hoboken, N.J.), 2(1), e70244. https://doi.org/10.1002/pmf2.70244
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
42597133
Department(s)
Administration and Leadership
Document Type
Article