One-step vs 2-step gestational diabetes mellitus screening and pregnancy outcomes: an updated systematic review and meta-analysis.

Authors

• Cintia Gomes
• Itamar D Futterman
• Olivia Sher
• Bracha Gluck
• Teresa A Hillier
• Fahimeh Ramezani Tehrani
• Nadim Chaarani
• Nelli Fisher
• Vincenzo Berghella
• Rodney A McLaren

Publication/Presentation Date

5-1-2024

Abstract

OBJECTIVE: This was a systematic review and meta-analysis comparing maternal and neonatal outcomes of patients screened with the 1-step or 2-step screening method for gestational diabetes mellitus.

DATA SOURCES: PubMed, Scopus, Cochrane, ClinicalTrials.gov, and LILACS were searched from inception up to September 2022.

STUDY ELIGIBILITY CRITERIA: Only randomized controlled trials were included. Studies that had overlapping populations were excluded (International Prospective Register of Systematic Review registration number: CRD42022358903).

METHODS: Risk ratios were computed with 95% confidence intervals by 2 authors. Unpublished data were requested. Large for gestational age was the primary outcome.

RESULTS: The search yielded 394 citations. Moreover, 7 randomized controlled trials met the inclusion criteria. A total of 54,650 participants were screened for gestational diabetes mellitus by either the 1-step screening method (n=27,163) or the 2-step screening method (n=27,487). For large for gestational age, there was no significant difference found between the groups (risk ratio, 0.99; 95% confidence interval, 0.93-1.05; I

CONCLUSION: Large for gestational age did not differ between patients screened using the 1-step screening method and those screened using the 2-step screening method. However, patients randomized to the 1-step screening method had higher rates of neonatal hypoglycemia and neonatal intensive care unit admission and maternal gestational diabetes mellitus diagnosis than the patients randomized to the 2-step screening method.

Volume

6

Issue

5

First Page

101346

Last Page

101346

ISSN

2589-9333

Published In/Presented At

Gomes, C., Futterman, I. D., Sher, O., Gluck, B., Hillier, T. A., Ramezani Tehrani, F., Chaarani, N., Fisher, N., Berghella, V., & McLaren, R. A., Jr (2024). One-step vs 2-step gestational diabetes mellitus screening and pregnancy outcomes: an updated systematic review and meta-analysis. American journal of obstetrics & gynecology MFM, 6(5), 101346. https://doi.org/10.1016/j.ajogmf.2024.101346

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

38479488

Department(s)

Administration and Leadership

Document Type

Article