Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies.
Publication/Presentation Date
9-26-2006
Abstract
We report five of 38 patients with stiff person syndrome (SPS), who also had cerebellar disease, gait ataxia, dysarthria, and oculomotor dysfunction (SPS-Cer). Cerebellar manifestations either preceded SPS or occurred concurrently. Brain MRI was normal. The intrathecal production of glutamic acid decarboxylase antibodies was elevated. Gamma-aminobutyric acid-enhancing drugs and immunotherapies improved only the stiffness. SPS-Cer is a distinct subset of SPS causing a more severe and complex clinical phenotype.
Volume
67
Issue
6
First Page
1068
Last Page
1070
ISSN
1526-632X
Published In/Presented At
Rakocevic, G., Raju, R., Semino-Mora, C., & Dalakas, M. C. (2006). Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies. Neurology, 67(6), 1068–1070. https://doi.org/10.1212/01.wnl.0000237558.83349.d0
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
17000981
Department(s)
Administration and Leadership
Document Type
Article