Postictal serotonin levels are associated with peri-ictal apnea.
Publication/Presentation Date
10-8-2019
Abstract
OBJECTIVE: To determine the relationship between serum serotonin (5-HT) levels, ictal central apnea (ICA), and postconvulsive central apnea (PCCA) in epileptic seizures.
METHODS: We prospectively evaluated video EEG, plethysmography, capillary oxygen saturation (SpO
RESULTS: Postictal serum 5-HT levels were increased over interictal levels for seizures without ICA (
CONCLUSIONS: The data suggest that significant seizure-related increases in serum 5-HT levels are associated with a lower incidence of seizure-related breathing dysfunction, and may reflect physiologic changes that confer a protective effect against deleterious phenomena leading to SUDEP. These results need to be confirmed with a larger sample size study.
Volume
93
Issue
15
First Page
1485
Last Page
1485
ISSN
1526-632X
Published In/Presented At
Murugesan, A., Rani, M. R. S., Vilella, L., Lacuey, N., Hampson, J. P., Faingold, C. L., Friedman, D., Devinsky, O., Sainju, R. K., Schuele, S., Diehl, B., Nei, M., Harper, R. M., Bateman, L. M., Richerson, G., & Lhatoo, S. D. (2019). Postictal serotonin levels are associated with peri-ictal apnea. Neurology, 93(15), e1485–e1494. https://doi.org/10.1212/WNL.0000000000008244
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
31484709
Department(s)
Administration and Leadership
Document Type
Article