Recombinant plasma gelsolin diminishes the acute inflammatory response to hyperoxia in mice.
Publication/Presentation Date
1-1-2002
Abstract
BACKGROUND: The acute respiratory distress syndrome remains a common and poorly understood complication of a variety of insults. Ventilation with high concentrations of inspired oxygen may further damage already compromised lungs. By scavenging extracellular actin and modulating the effects of lysophosphatidic acid, plasma gelsolin could serve a critical protective role against oxidant injury.
METHODS: Mice exposed to >95% O2 for a total of 72 hours were treated with gelsolin or albumin after 24 and 48 hours.
RESULTS: Neutrophil counts in bronchoalveolar fluid rose (P=0.0002) and gelsolin levels dropped (P< 0.00001) in mice with acute hyperoxic lung injury. The acute inflammatory response to hyperoxia was significantly reduced in the gelsolin- compared with the bovine serum albumin-treated mice (P=0.03).
CONCLUSIONS: These data imply that i) gelsolin depletion contributes to the pathogenesis of oxygen toxicity and ii) repletion of gelsolin can partially abrogate the resultant exudative response.
Volume
50
Issue
1
First Page
54
Last Page
60
ISSN
1081-5589
Published In/Presented At
Christofidou-Solomidou, M., Scherpereel, A., Solomides, C. C., Christie, J. D., Stossel, T. P., Goelz, S., & DiNubile, M. J. (2002). Recombinant plasma gelsolin diminishes the acute inflammatory response to hyperoxia in mice. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 50(1), 54–60. https://doi.org/10.2310/6650.2002.33518
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
11813829
Department(s)
Administration and Leadership
Document Type
Article