Next Generation Development of Hybrid Continuous Flow Pediatric Total Artificial Heart Technology: Design-Build-Test.

Authors

• Matthew D Hirschhorn
• Jonathan E M Lawley
• Andrew J Roof
• Arthur P T Johnson
• William A Stoddard
• Randy M Stevens
• Joseph Rossano
• Francisco Arabia
• Vakhtang Tchantchaleishvili
• H Todd Massey
• Steven W Day
• Amy L Throckmorton

Publication/Presentation Date

12-1-2023

Abstract

To address the unmet clinical need for pediatric circulatory support, we are developing an operationally versatile, hybrid, continuous-flow, total artificial heart ("Dragon Heart"). This device integrates a magnetically levitated axial and centrifugal blood pump. Here, we utilized a validated axial flow pump, and we focused on the development of the centrifugal pump. A motor was integrated to drive the centrifugal pump, achieving 50% size reduction. The motor design was simulated by finite element analysis, and pump design improvement was attained by computational fluid dynamics. A prototype centrifugal pump was constructed from biocompatible 3D printed parts for the housing and machined metal parts for the drive system. Centrifugal prototype testing was conducted using water and then bovine blood. The fully combined device ( i.e. , axial pump nested inside of the centrifugal pump) was tested to ensure proper operation. We demonstrated the hydraulic performance of the two pumps operating in tandem, and we found that the centrifugal blood pump performance was not adversely impacted by the simultaneous operation of the axial blood pump. The current iteration of this design achieved a range of operation overlapping our target range. Future design iterations will further reduce size and incorporate complete and active magnetic levitation.

Volume

69

Issue

12

First Page

1090

Last Page

1098

ISSN

1538-943X

Published In/Presented At

Hirschhorn, M. D., Lawley, J. E. M., Roof, A. J., Johnson, A. P. T., Stoddard, W. A., Stevens, R. M., Rossano, J., Arabia, F., Tchantchaleishvili, V., Massey, H. T., Day, S. W., & Throckmorton, A. L. (2023). Next Generation Development of Hybrid Continuous Flow Pediatric Total Artificial Heart Technology: Design-Build-Test. ASAIO journal (American Society for Artificial Internal Organs : 1992), 69(12), 1090–1098. https://doi.org/10.1097/MAT.0000000000002043

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

37774695

Department(s)

Administration and Leadership

Document Type

Article