Acute Amiodarone Pulmonary Toxicity.
Publication/Presentation Date
5-1-2021
Abstract
Amiodarone is an effective antiarrhythmic that frequently is used during the perioperative period. Amiodarone possesses a significant adverse reaction profile. Amiodarone-induced pulmonary toxicity (AIPT) is among the most serious adverse effects and is a leading cause of death associated with its use. Despite significant advances in the understanding of AIPT, its etiology and pathogenesis remain incompletely understood. The diagnosis of AIPT is one of exclusion. The clinical manifestations of AIPT are categorized broadly as acute, subacute, and chronic. Acute AIPT is a rarer and more aggressive form of the disease, most often encountered in cardiothoracic surgery. Acute respiratory distress syndrome (ARDS) is the predominating pattern of amiodarone's acute pulmonary toxicity. The incidence, risk factors, pathogenesis, and diagnosis of acute AIPT are speculative. Early cardiothoracic literature investigating AIPT often attributed amiodarone to the development of postoperative ARDS. Subsequent studies have found no association between amiodarone and acute AIPT and ARDS development. As a drug that is frequently prescribed to a patient population deemed most at risk for this fatal disease, the conflicting evidence on acute AIPT needs further investigation and clarification.
Volume
35
Issue
5
First Page
1485
Last Page
1494
ISSN
1532-8422
Published In/Presented At
Feduska, E. T., Thoma, B. N., Torjman, M. C., & Goldhammer, J. E. (2021). Acute Amiodarone Pulmonary Toxicity. Journal of cardiothoracic and vascular anesthesia, 35(5), 1485–1494. https://doi.org/10.1053/j.jvca.2020.10.060
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
33262034
Department(s)
Administration and Leadership
Document Type
Article