HIF-1α and miR-210 differential and lineage-specific expression in systemic lupus erythematosus.
Publication/Presentation Date
5-1-2021
Abstract
Systemic lupus erythematosus (SLE, lupus) is a chronic autoimmune disease characterized by loss of peripheral tolerance to nuclear self-antigens. It is increasingly recognized that aberrant T cell metabolism is a critical mediator of SLE immunopathology. Hypoxia inducible factor 1⍺ (HIF-1α) is a key transcription factor that regulates T cell metabolism in response to immune stimuli. T cell activation induces HIF-1α expression and transcriptional activation of HIF-responsive genes. HypoxamiRs are a group of microRNAs sensitive to HIF-1α transcriptional regulation that function to fine-tune the HIF-driven transcriptional program. The 'master' hypoxamiR, miR-210 is transcriptionally regulated by HIF-1α and negatively regulates HIF-1α activity. Although a key role for HIF-1α in has been described in a number of autoimmune and inflammatory diseases and abnormal microRNA expression profiles correlate with poor clinical outcome in a number of rheumatologic diseases, the expression and function of HIF-1α and miR-210 in lupus remains largely uncharacterized. Here we report HIF-1α and miR-210 differential and lineage-specific expression in systemic lupus erythematosus. We show that HIF-1α mRNA and protein is overexpressed in human lupus CD4
Volume
133
First Page
128
Last Page
134
ISSN
1872-9142
Published In/Presented At
Garchow, B., Maque Acosta, Y., & Kiriakidou, M. (2021). HIF-1α and miR-210 differential and lineage-specific expression in systemic lupus erythematosus. Molecular immunology, 133, 128–134. https://doi.org/10.1016/j.molimm.2021.02.019
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
33657462
Department(s)
Administration and Leadership
Document Type
Article