Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region.

Authors

• M Kiriakidou
• D A Driscoll
• J M Lopez-Guisa
• J F Strauss

Publication/Presentation Date

11-1-1997

Abstract

Murine Daxx, a protein that binds to Fas and enhances Fas-mediated apoptosis through a signal transduction pathway involving the Jun amino-terminal kinase, was recently described. Here we report the cloning of human and monkey Daxx cDNAs, the widespread expression of Daxx mRNA in human tissues, and the mapping of the human Daxx gene to 6p21.3 in the major histocompatibility complex (MHC) region. The location of the Daxx gene, which is implicated in the pathway for deletion of autoreactive lymphocytes, in the MHC region may shed light on the genetic basis of autoimmune diseases.

Volume

16

Issue

11

First Page

1289

Last Page

1298

ISSN

1044-5498

Published In/Presented At

Kiriakidou, M., Driscoll, D. A., Lopez-Guisa, J. M., & Strauss, J. F., 3rd (1997). Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region. DNA and cell biology, 16(11), 1289–1298. https://doi.org/10.1089/dna.1997.16.1289

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

9407001

Department(s)

Administration and Leadership

Document Type

Article