Outcome of Patients Presenting With High-Risk Pulmonary Embolism Treated With Mechanical Thrombectomy: A Subgroup Analysis From the STRIKE-PE Study.

Publication/Presentation Date

5-1-2026

Abstract

BACKGROUND: High-risk pulmonary embolism (PE), defined as PE causing hemodynamic instability, remains associated with high acute mortality and currently warrants acute treatment with systemic thrombolysis. Mechanical thrombectomy can be considered where thrombolysis is inappropriate, as an alternative, or in addition to, but more prospective data are needed. This analysis evaluates the safety, effectiveness, functional, and quality of life (QoL) outcomes in high-risk PE patients who were treated using mechanical thrombectomy with computer-assisted vacuum thrombectomy (CAVT) devices.

METHODS: Among the first 595 patients enrolled in the prospective, international STRIKE-PE study, 48 were identified as having high-risk PE. Outcomes included change in right-to-left ventricular ratio from baseline to 48-hour follow-up, 48-hour composite major adverse events (MAE), additional safety end points, and 90-day changes in functional and QoL assessments.

RESULTS: Mean right-to-left ventricular ratio decreased from 1.50 ± 0.36 to 1.02 ± 0.18 (

CONCLUSIONS: CAVT for high-risk PE was feasible and associated with a low incidence of MAE and a low 30-day mortality rate. CAVT treatment facilitated improvements in hemodynamic status and RV strain. Dyspnea, distance walked, functional status, and QoL significantly improved.

Volume

5

Issue

5

First Page

104402

Last Page

104402

ISSN

2772-9303

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

42183133

Department(s)

Administration and Leadership

Document Type

Article

Link to Full Text

Share

COinS