Epidemiology of healthcare-associated ventriculitis and meningitis (HCAVM) and community-acquired meningitis/encephalitis and evaluation of an off-label PCR panel for HCAVM diagnosis.
Publication/Presentation Date
2-3-2026
Abstract
Healthcare-associated ventriculitis and meningitis (HCAVM) is associated with high morbidity and mortality, but rapid diagnostic tests intended to cover microorganisms that typically cause HCAVM are not commercially available. We sought to evaluate the etiology of HCAVM compared to community-acquired meningitis/encephalitis (CAME) at our healthcare system, and to study the utility of repurposing a multiplex molecular panel intended for positive blood cultures for HCAVM cases. Our epidemiologic review demonstrated that HCAVM cases were primarily caused by bacteria and fungi also associated with bloodstream infections, in contrast with CAME cases, which were primarily caused by herpesviruses and
Volume
14
Issue
2
First Page
0277025
Last Page
0277025
ISSN
2165-0497
Published In/Presented At
Nassur, J. A., Schnell, K. M., Dolon, C. D., Walters, L., Weber, D., & Pettengill, M. A. (2026). Epidemiology of healthcare-associated ventriculitis and meningitis (HCAVM) and community-acquired meningitis/encephalitis and evaluation of an off-label PCR panel for HCAVM diagnosis. Microbiology spectrum, 14(2), e0277025. https://doi.org/10.1128/spectrum.02770-25
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
41451990
Department(s)
Administration and Leadership
Document Type
Article