Late-onset recurrent lupus nephritis in a kidney transplant recipient.
Publication/Presentation Date
1-1-2026
Abstract
Long-term kidney allograft survival continues to be a challenge, despite improvements in the short term. Recurrence of glomerular disease is a significant cause of allograft failure. We report a case of graft dysfunction 27 years post transplant attributed to biopsy-proven recurrent class IV lupus nephritis. Following targeted medication adjustments aimed at treating lupus nephritis, the patient achieved complete remission within 6 months, which has been sustained for 4 years. Although recurrent lupus nephritis is reported to occur up to 16 years after transplantation, it is uncommon, and represents a potentially treatable cause of graft failure. This report underscores the critical need for heightened awareness and prompt management of recurrent lupus nephritis regardless of the time post transplant to enhance long-term allograft survival. Furthermore, our case highlights that positive allograft staining in peritubular capillaries for C4d may result from recurrent immune-complex disease as opposed to antibody-mediated rejection.
Volume
14
First Page
24
Last Page
29
ISSN
2196-5293
Published In/Presented At
Cobb, J. K., Endres, P., Shenoy, P., Filippone, E. J., Gupta, M., & Gulati, R. (2026). Late-onset recurrent lupus nephritis in a kidney transplant recipient. Clinical nephrology. Case studies, 14, 24–29. https://doi.org/10.5414/CNCS111897
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
42131772
Department(s)
Administration and Leadership
Document Type
Article