Recurrent bleeding duodenal and colonic ulcers due to post-transplant lymphoproliferative disorder.
Publication/Presentation Date
2-1-2023
Abstract
Post-transplant lymphoproliferative disorder (PTLD) is a rare complication of solid organ transplantation as the result of immunosuppressant medications. Epstein-Barr virus (EBV) has been implicated in most of these cases, specifically with B-cell predominant lymphoma. This case report describes a 24-year-old female who presented with recurrent GI bleed within 6 months post-orthostatic heart transplant. Endoscopic evaluations including video capsule study, push enteroscopy, and colonoscopy revealed multiple ulcerated lesions in duodenum, jejunum, and colon secondary to Epstein-Barr Virus-associated monomorphic PTLD. Despite continuation of rituximab after discharge, she returned to the hospital for recurrent GI bleed requiring additional endoscopic intervention. PTLD is a devastating disease of the post-transplant population. Due to a high risk of recurrent GI bleeding, patients with PTLD may benefit from careful monitoring by gastroenterology as an outpatient with a low threshold for repeat endoscopic evaluation despite being on immunotherapy or chemotherapy.
Volume
16
Issue
1
First Page
39
Last Page
42
ISSN
1865-7265
Published In/Presented At
Mitsuhashi, S., Chalikonda, D., Nazir, B., Agarwal, A., & Coben, R. (2023). Recurrent bleeding duodenal and colonic ulcers due to post-transplant lymphoproliferative disorder. Clinical journal of gastroenterology, 16(1), 39–42. https://doi.org/10.1007/s12328-022-01718-1
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
36251246
Department(s)
Administration and Leadership
Document Type
Article