Rates of Cancer, Non-curative Resection, Adverse Event and Surgery After Colonic Endoscopic Submucosal Dissection (ESD)-Results from a Large International Multicenter Study.

Authors

• Rahul Karna
• Jonathan Colón Sánchez
• Kevan Josloff
• Tammy Tran
• Kasenee Tiankanon
• Saowanee Ngamruengphong
• Elisabet Maristany Bosch
• Georgios Kalopitas
• Edward John Despott
• Alberto Murino
• Shaimaa Elkholy
• Mohamed El Sherbiny
• Karim Essam
• Hany Haggag
• Abeer Awad Abdallatef
• Kerolis Yousef
• Rossella Maresca
• Federico Barbaro
• Galen Leung
• Frances Dang
• Amirali Tavangar
• Jason Samarasena
• Ahmed Saeed
• Sherif Andrawes
• Yutaka Tomizawa
• Mohammad Bilal
• Kartik Sampath
• Yasi Xiao
• Faisal Kamal
• Thomas Kowalski
• Alexander Schlachterman
• Anand R Kumar

Publication/Presentation Date

6-1-2026

Abstract

BACKGROUND AND AIMS: Endoscopic submucosal dissection (ESD) is preferred over endoscopic mucosal resection (EMR) for resection of colon cancer with suspected superficial invasion. Data on appropriate utilization of ESD such as rates of cancer and non-curative resection (NCR) are under-reported.

METHODS: Retrospective multicenter study of 547 consecutive colonic lesions undergoing ESD was performed. Outcomes were rates of cancer, NCR, surgery and predictors of NCR.

RESULTS: Of all lesions, histopathology demonstrated cancer in 12% (n = 66). Overall, NCR was seen in 59.1% (n = 39) patients and 24.6% (n = 135) lesions contained high-grade dysplasia. For NCR, patients underwent surgery in 7.6% (n = 3) and adverse events were observed in 8.8% (n = 48).

CONCLUSIONS: In our large multicenter Western cohort, the pathology was found to be benign in most of the colon ESDs and there was high NCR for resected lesions with cancer. The overall surgery rate, however, remained low. This study highlights the need to refine lesion selection criteria while continuing to optimize ESD technique to match the efficiency and safety of EMR.

Volume

71

Issue

6

First Page

2508

Last Page

2513

ISSN

1573-2568

Published In/Presented At

Karna, R., Sánchez, J. C., Josloff, K., Tran, T., Tiankanon, K., Ngamruengphong, S., Bosch, E. M., Kalopitas, G., Despott, E. J., Murino, A., Elkholy, S., Sherbiny, M. E., Essam, K., Haggag, H., Abdallatef, A. A., Yousef, K., Maresca, R., Barbaro, F., Leung, G., Dang, F., … Kumar, A. R. (2026). Rates of Cancer, Non-curative Resection, Adverse Event and Surgery After Colonic Endoscopic Submucosal Dissection (ESD)-Results from a Large International Multicenter Study. Digestive diseases and sciences, 71(6), 2508–2513. https://doi.org/10.1007/s10620-025-09621-8

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

41402609

Department(s)

Administration and Leadership

Document Type

Article