Is single-cell apoptosis sufficient for the diagnosis of graft-versus-host disease in the colon?
Publication/Presentation Date
3-1-2008
Abstract
Low-grade lesions of graft-versus-host disease (GVHD) in the colon are not uncommon. To determine if minimal diagnostic criteria can be established in such biopsies, we correlated histologic findings with clinical history and investigated the role of endoscopy and electron microscopy in establishing GVHD. About 85 colonic biopsies that were histologically consistent with GVHD from 47 bone-marrow transplant recipients were reviewed retrospectively. Of nine cases showing only a single apoptotic cell in the intestinal epithelium, only four lacked any confounding factors of GVHD. These cases, while too few to assess the utility of finding one apoptotic cell with statistical significance, appear to support the idea that in the appropriate clinical setting, a single apoptotic cell could be reported as possibly representing early GVHD. Endoscopic findings did not reliably correlate with histology. Although electron microscopy can be a useful adjunct, it does not contribute to the diagnosis of GVHD.
Volume
53
Issue
3
First Page
747
Last Page
756
ISSN
0163-2116
Published In/Presented At
Nguyen, C. V., Kastenberg, D. M., Choudhary, C., Katz, L. C., DiMarino, A., & Palazzo, J. P. (2008). Is single-cell apoptosis sufficient for the diagnosis of graft-versus-host disease in the colon?. Digestive diseases and sciences, 53(3), 747–756. https://doi.org/10.1007/s10620-007-9904-3
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
18060495
Department(s)
Administration and Leadership
Document Type
Article