Ovarian leydig cell hyperplasia: an unusual case of virilization in a postmenopausal woman.
Publication/Presentation Date
1-1-2014
Abstract
Objective. To report an unusual case of ovarian Leydig cell hyperplasia resulting in virilization in a postmenopausal woman. Methods. Patient's medical history and pertinent literature were reviewed. Results. A 64-year-old woman presented with virilization with worsening hirsutism, deepening of her voice, male musculature, and male pattern alopecia. Her pertinent past medical history included type 1 diabetes, hyperlipidemia, and hypertension. Her pertinent past surgical history included hysterectomy due to fibroids. On further work-up, her serum total testosterone was 506 ng/dL (nl range: 2-45) and free testosterone was 40 pg/mL (nl range: 0.1-6.4). After ruling out adrenal causes, the patient underwent an empiric bilateral oophorectomy that showed Leydig cell hyperplasia on pathology. Six weeks postoperatively, serum testosterone was undetectable with significant clinical improvement. Conclusion. Postmenopausal hyperandrogenism can be the result of numerous etiologies ranging from normal physiologic changes to ovarian or rarely adrenal tumors. Our patient was found to have Leydig cell hyperplasia of her ovaries, a rarely reported cause of virilization.
Volume
2014
First Page
762745
Last Page
762745
ISSN
2090-6501
Published In/Presented At
Mehta, J. M., Miller, J. L., Cannon, A. J., Mardekian, S. K., Kenyon, L. C., & Jabbour, S. A. (2014). Ovarian leydig cell hyperplasia: an unusual case of virilization in a postmenopausal woman. Case reports in endocrinology, 2014, 762745. https://doi.org/10.1155/2014/762745
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
25045549
Department(s)
Administration and Leadership
Document Type
Article