When delivery matters: Diffuse coronary vasospasm with continuous, but not bolus, 5-FU infusion.
Publication/Presentation Date
12-31-2025
Abstract
5-Fluorouracil (5-FU) is a fluorinated pyrimidine chemotherapy analogue used to treat various gastrointestinal solid malignancy. It is known to be associated with cardiotoxicity. Here, we present a case of 58-year-old male with mucinous adenocarcinoma of the sigmoid colon who experienced global coronary vasospasm in setting of continuous 5-FU infusion refractory to prophylactic antianginal treatment. However, he was asymptotic when given bolus of 5-FU. Our case highlights the difference in toxicity between continuous and bolus 5-FU therapy and emphasizes the need for further research in the pathophysiology and treatment of cardiotoxicity related to 5-FU therapy.
Volume
2025
Issue
6
First Page
202561
Last Page
202561
ISSN
2305-7823
Published In/Presented At
Salman Sabri, M., Talukder, Z., Bedi, A., & Cho, S. H. (2025). When delivery matters: Diffuse coronary vasospasm with continuous, but not bolus, 5-FU infusion. Global cardiology science & practice, 2025(6), e202561. https://doi.org/10.21542/gcsp.2025.61
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
41978898
Department(s)
Administration and Leadership
Document Type
Article