Successful use of quinine in the treatment of electrical storm in a child with Brugada syndrome.
Publication/Presentation Date
5-1-2011
Abstract
A 10-year-old girl developed life-threatening recurrent polymorphic ventricular tachycardia following surgical closure of a simple secundum atrial septal defect. Post hoc analysis of a Holter recording suggested Brugada syndrome. After managing the acute phase, a dual chamber defibrillator was implanted. One week later she experienced VF storm, needing 96 appropriate shocks within a few hours. Quinidine, by virtue of its I(to) blocking property, is the only drug reported to be useful in managing VF storm in Brugada syndrome. Nonavailability of quinidine led us to try its diastereomer, intravenous quinine, which succeeded in controlling the ventricular tachycardia. Arrhythmia storm in the setting of ion channelopathy can be difficult to manage, and sometimes requires innovative therapies.
Volume
22
Issue
5
First Page
594
Last Page
597
ISSN
1540-8167
Published In/Presented At
Mehrotra, S., Juneja, R., Naik, N., & Pavri, B. B. (2011). Successful use of quinine in the treatment of electrical storm in a child with Brugada syndrome. Journal of cardiovascular electrophysiology, 22(5), 594–597. https://doi.org/10.1111/j.1540-8167.2010.01907.x
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
21040093
Department(s)
Administration and Leadership
Document Type
Article