Regulation of pml messenger-RNA expression in human breast-carcinoma cells.

Authors

• X Li
• M Sheikh
• Z Shao
• S Lanzkron
• J Chen
• J Fontana

Publication/Presentation Date

11-1-1994

Abstract

We examined the mRNA expression profile of PML, a novel nuclear protein recently characterized from acute promyelocytic leukemia (APL) blast cells, in a number of breast carcinoma cell lines. PML mRNA was found to be differentially expressed among the cell lines examined. A correlation of borderline significance between PML mRNA expression and the proliferative capacity of the cell Lines was noted. Serum stimulation significantly elevated the PML mRNA levels in the T47D and MDA-MB-231 cells. These results would suggest that PML may function as a positive regulator of cellular proliferation in breast carcinoma cells.

Volume

5

Issue

5

First Page

1177

Last Page

1181

ISSN

1019-6439

Published In/Presented At

Li, X., Sheikh, M., Shao, Z., Lanzkron, S., Chen, J., & Fontana, J. (1994). Regulation of pml messenger-RNA expression in human breast-carcinoma cells. International journal of oncology, 5(5), 1177–1181. https://doi.org/10.3892/ijo.5.5.1177

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

21559697

Department(s)

Administration and Leadership

Document Type

Article