Sickle cell disease and venous thromboembolism: what the anticoagulation expert needs to know.
Publication/Presentation Date
4-1-2013
Abstract
Venous thromboembolism (VTE) is common in patients with sickle cell disease (SCD). The etiology of increased risk of VTE in SCD patients is multifactorial and is related to both traditional factors and SCD-specific factors. Traditional risk factors such as central venous catheters, frequent hospitalization, orthopedic surgeries for avascular necrosis, and pregnancy may lead to increased incidence of VTE in the SCD population. In addition, SCD itself appears to be a hypercoagulable state, and many SCD-specific factors such as thrombophilic defects, genotype and splenectomy may modify the risk of VTE. SCD complications such as acute chest syndrome and pulmonary hypertension may also be related to VTE. Anticoagulation experts should be aware of these factors to help inform prophylaxis and treatment decisions.
Volume
35
Issue
3
First Page
352
Last Page
358
ISSN
1573-742X
Published In/Presented At
Naik, R. P., Streiff, M. B., & Lanzkron, S. (2013). Sickle cell disease and venous thromboembolism: what the anticoagulation expert needs to know. Journal of thrombosis and thrombolysis, 35(3), 352–358. https://doi.org/10.1007/s11239-013-0895-y
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
23435703
Department(s)
Administration and Leadership
Document Type
Article