IGFBP3 Modulates Lung Tumorigenesis and Cell Growth through IGF1 Signaling.

Authors

Yong Antican Wang
Yunguang Sun
Joshua Palmer
Charalambos Solomides
Li-Ching Huang
Yu Shyr
Adam P Dicker
Bo Lu

Publication/Presentation Date

7-1-2017

Abstract

Insulin-like growth factor binding protein 3 (IGFBP3) modulates cell growth through IGF-dependent and -independent mechanisms. Reports suggest that the serum levels of IGFBP3 are associated with various cancers and that IGFBP3 expression is significantly decreased in cisplatin (CDDP)-resistant lung cancer cells. Based on these findings, we investigated whether

Volume

15

Issue

7

First Page

896

Last Page

904

ISSN

1557-3125

Published In/Presented At

Wang, Y. A., Sun, Y., Palmer, J., Solomides, C., Huang, L. C., Shyr, Y., Dicker, A. P., & Lu, B. (2017). IGFBP3 Modulates Lung Tumorigenesis and Cell Growth through IGF1 Signaling. Molecular cancer research : MCR, 15(7), 896–904. https://doi.org/10.1158/1541-7786.MCR-16-0390

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

28330997

Department(s)

Administration and Leadership

Document Type

Article