Mental health, pain and likelihood of opioid misuse among adults with sickle cell disease.

Authors

• Charles R Jonassaint
• Ektha Parchuri
• Julia A O'Brien
• Christina M Lalama
• Jonathan Lin
• Sherif M Badawy
• Megan E Hamm
• Jennifer Stinson
• Chitra Lalloo
• C Patrick Carroll
• Santosh L Saraf
• Victor R Gordeuk
• Robert Cronin
• Nirmish Shah
• Sophie M Lanzkron
• Darla Liles
• Cassandra Trimnell
• Lakiea Bailey
• Raymona H Lawrence
• Kaleab Z Abebe

Publication/Presentation Date

3-1-2024

Abstract

Depressive symptoms are prevalent in individuals living with sickle cell disease (SCD) and may exacerbate pain. This study examines whether higher depressive symptoms are associated with pain outcomes, pain catastrophizing, interference and potential opioid misuse in a large cohort of adults with SCD. The study utilized baseline data from the 'CaRISMA' trial, which involved 357 SCD adults with chronic pain. Baseline assessments included pain intensity, daily mood, the Patient Health Questionnaire (PHQ), the Generalized Anxiety Disorders scale, PROMIS Pain Interference, Pain Catastrophizing Scale, the Adult Sickle Cell Quality of Life Measurement Information System and the Current Opioid Misuse Measure. Participants were categorized into 'high' or 'low' depression groups based on PHQ scores. Higher depressive symptoms were significantly associated with increased daily pain intensity, negative daily mood, higher pain interference and catastrophizing, poorer quality of life and a higher likelihood of opioid misuse (all p <  0.01). SCD patients with more severe depressive symptoms experienced poorer pain outcomes, lower quality of life and increased risk of opioid misuse. Longitudinal data from this trial will determine whether addressing depressive symptoms may potentially reduce pain frequency and severity in SCD.

Volume

204

Issue

3

First Page

1029

Last Page

1038

ISSN

1365-2141

Published In/Presented At

Jonassaint, C. R., Parchuri, E., O'Brien, J. A., Lalama, C. M., Lin, J., Badawy, S. M., Hamm, M. E., Stinson, J., Lalloo, C., Carroll, C. P., Saraf, S. L., Gordeuk, V. R., Cronin, R., Shah, N., Lanzkron, S. M., Liles, D., Trimnell, C., Bailey, L., Lawrence, R. H., & Abebe, K. Z. (2024). Mental health, pain and likelihood of opioid misuse among adults with sickle cell disease. British journal of haematology, 204(3), 1029–1038. https://doi.org/10.1111/bjh.19243

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

38171495

Department(s)

Administration and Leadership

Document Type

Article