Preoperative Blood Transfusions and Morbidity in Neonates Undergoing Surgery.
Publication/Presentation Date
11-1-2020
Abstract
BACKGROUND: Blood transfusions in the neonatal patient population are common, but there are no established guidelines regarding transfusion thresholds. Little is known about postoperative outcomes in neonates who receive preoperative blood transfusions (PBTs).
METHODS: Using the American College of Surgeons National Surgical Quality Improvement Program-Pediatric Participant Use Data Files from 2012 to 2015, we identified all neonates who underwent surgery. Mortality and composite morbidity (defined as any postoperative complication) in neonates who received a PBT within 48 hours of surgery were compared with that in neonates who did not receive a transfusion.
RESULTS: A total of 12 184 neonates were identified, of whom 1209 (9.9%) received a PBT. Neonates who received a PBT had higher rates of preoperative comorbidities and worse postoperative outcomes when compared with those who did not receive a transfusion (composite morbidity: 46.2% vs 16.2%;
CONCLUSIONS: In a propensity score-matched model, PBTs are independently associated with increased morbidity and mortality in neonates who undergo surgery. Prospective data are needed to better understand the potential effects of a red blood cell transfusion in this patient population.
Volume
146
Issue
5
ISSN
1098-4275
Published In/Presented At
Dukleska, K., Vinocur, C. D., Brenn, B. R., Lim, D. J., Keith, S. W., Dirnberger, D. R., & Berman, L. (2020). Preoperative Blood Transfusions and Morbidity in Neonates Undergoing Surgery. Pediatrics, 146(5), e20193718. https://doi.org/10.1542/peds.2019-3718
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
33087550
Department(s)
Administration and Leadership
Document Type
Article