Keloid excision and recurrence prophylaxis via intradermal interferon-gamma injections: a pilot study.
Publication/Presentation Date
12-1-1996
Abstract
Keloids are an abnormal response to wound healing distinguished by an overproduction of collagen. Thickened bundles of collagen in the reticular dermis oriented haphazardly in relation to the overlying epithelium are found in keloids, in contrast to thinner collagen fibers in a more orderly arrangement that are found in normal scars. Previous clinical trials of intralesional interferon-gamma (IFN-G) injections by Larrabee et al. and Granstein et al. showed a decrease in lesion size. These findings led to a conclusion that IFN-G would be a useful adjunct to surgical excision of keloids to aid in preventing recurrence. We performed a double-blind, placebo-controlled trial in patients with two or more keloids treated with excision and subsequent local injections of IFN-G or placebo.
Volume
106
Issue
12 Pt 1
First Page
1497
Last Page
1501
ISSN
0023-852X
Published In/Presented At
Broker, B. J., Rosen, D., Amsberry, J., Schmidt, R., Sailor, L., Pribitkin, E. A., & Keane, W. M. (1996). Keloid excision and recurrence prophylaxis via intradermal interferon-gamma injections: a pilot study. The Laryngoscope, 106(12 Pt 1), 1497–1501. https://doi.org/10.1097/00005537-199612000-00010
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
8948610
Department(s)
Administration and Leadership
Document Type
Article