Low absolute risk of thrombotic and cardiovascular events in outpatient pregnant women with COVID-19.
Publication/Presentation Date
5-1-2024
Abstract
INTRODUCTION: Pregnancy may contribute to an excess risk of thrombotic or cardiovascular events. COVID-19 increases the risk of these events, although the risk is relatively limited among outpatients. We sought to determine whether outpatient pregnant women with COVID-19 are at a high risk for cardiovascular or thrombotic events.
MATERIALS & METHODS: We analyzed pregnant outpatients with COVID-19 from the multicenter CORONA-VTE-Network registry. The main study outcomes were a composite of adjudicated venous or arterial thrombotic events, and a composite of adjudicated cardiovascular events. Events were assessed 90 days after the COVID-19 diagnosis and reported for non-pregnant women ≤45 years, and for men ≤45 years, as points of reference.
RESULTS: Among 6585 outpatients, 169 were pregnant at diagnosis. By 90-day follow-up, two pregnant women during the third trimester had lower extremity venous thrombosis, one deep and one superficial vein thrombosis. The cumulative incidence of thrombotic events was 1.20 % (95 % confidence interval [CI]: 0.0 to 2.84 %). Respective rates were 0.47 % (95 % CI: 0.14 % to 0.79 %) among non-pregnant women, and 0.49 % (95 % CI: 0.06 % to 0.91 %) among men ≤45 years. No non-thrombotic cardiovascular events occurred in pregnant women. The rates of cardiovascular events were 0.53 % (95 % CI: 0.18 to 0.87) among non-pregnant women, and 0.68 % (95 % CI: 0.18 to 1.18) in men aged ≤45 years.
CONCLUSIONS: Thrombotic and cardiovascular events are rare among outpatients with COVID-19. Although a higher event rate among outpatient pregnant women cannot be excluded, the absolute event rates are low and do not warrant population-wide cardiovascular interventions to optimize outcomes.
Volume
237
First Page
209
Last Page
215
ISSN
1879-2472
Published In/Presented At
Bikdeli, B., Krishnathasan, D., Khairani, C. D., Bejjani, A., Davies, J., Porio, N., Tristani, A., Armero, A., Assi, A. A., Nauffal, V., Campia, U., Almarzooq, Z., Wei, E., Ortiz-Rios, M. D., Zuluaga-Sánchez, V., Achanta, A., Jesudasen, S. J., Tiu, B., Merli, G. J., Leiva, O., … CORONA-VTE-Network Investigators (2024). Low absolute risk of thrombotic and cardiovascular events in outpatient pregnant women with COVID-19. Thrombosis research, 237, 209–215. https://doi.org/10.1016/j.thromres.2024.02.021
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
38677791
Department(s)
Administration and Leadership
Document Type
Article