Adjudicated Cardiovascular Events in Patients With COVID-19: Association With Vaccination Status and Changes over Time.
Publication/Presentation Date
12-16-2025
Abstract
BACKGROUND: Patients with COVID-19 are at risk of thrombotic and cardiovascular complications. Existing risk estimates derive from early COVID-19 experiences. More recent event rates, temporal trends, and the association between vaccination status and cardiovascular outcomes remain unclear.
METHODS: The CORONA-VTE Network (COVID-19 Registry to Assess Frequency, Risk Factors, Management, and Outcomes of Arterial and Venous Thromboembolic Complications) multicenter registry included patients with COVID-19 from March 2020 to February 2024. A composite of venous and arterial thrombotic events and a composite of adjudicated cardiovascular events were assessed at 90 days after COVID-19 diagnosis. Time-to-first-event analyses were stratified by inpatients and outpatients and adjusted for competing risks. Outcomes were adjudicated by independent physicians.
RESULTS: Of 11 165 patients, 4451 were inpatients (mean age, 65 years; 47% women) and 462 of 4451 were admitted to the intensive care unit. Among inpatients, the 90-day cumulative incidences of thrombotic and cardiovascular events were 8.9% (95% CI, 8.0%-9.8%) and 15.6% (95% CI, 14.5%-16.7%), respectively. Corresponding estimates for patients in the intensive care unit were 20.0% (95% CI, 16.6%-24.0%) and 30.7% (95% CI, 26.8%-35.3%), while event rates were low among outpatients. There was an initial decline in cardiovascular events (adjusted hazard ratio [HR], 0.84;
CONCLUSIONS: Thrombotic and cardiovascular events are common in hospitalized patients with COVID-19, especially those in the intensive care unit, without a persistent decline over time. COVID-19 vaccination was associated with a reduced risk of cardiovascular events.
Volume
14
Issue
24
First Page
044011
Last Page
044011
ISSN
2047-9980
Published In/Presented At
Bikdeli, B., Krishnathasan, D., Bejjani, A., Khairani, C. D., Hamade, N., Campia, U., Davies, J., Porio, N., Assi, A., Armero, A., Tristani, A., Ortiz-Rios, M. D., Nauffal, V., Almarzooq, Z. I., Wei, E. Q., McGonagle, B., Pfeferman, M., Rashedi, S., Sato, A., Scimeca, G., … CORONA‐VTE Network Investigators (2025). Adjudicated Cardiovascular Events in Patients With COVID-19: Association With Vaccination Status and Changes over Time. Journal of the American Heart Association, 14(24), e044011. https://doi.org/10.1161/JAHA.125.044011
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
41378506
Department(s)
Administration and Leadership
Document Type
Article