Association between Active Cancer and Risk of Thrombotic and Cardiovascular Outcomes in Outpatients with COVID-19: A CORONA-VTE Network Analysis.
Publication/Presentation Date
1-1-2025
Abstract
UNLABELLED: Coronavirus disease 2019 (COVID-19) and active cancer are each independently associated with excess risk of thrombotic and cardiovascular events. However, data are limited regarding the risk of these events in outpatients with active cancer and concomitant COVID-19.
OBJECTIVES: This study aimed to retrospectively examine the association between active cancer and thrombotic and cardiovascular outcomes among non-hospitalized patients with COVID-19.
METHODS: Data from the outpatient cohort with confirmed COVID-19 from the 10,420-patient multicenter U.S. CORONA-VTE Network registry were used. Active cancer was defined as having a malignancy diagnosis (excluding non-melanoma skin cancer) or receiving cancer-related treatment within the past year. Outcomes were independently adjudicated and included a composite of venous and arterial thromboembolism, and a composite of major adverse cardiovascular events, including thromboembolism, heart failure, myocarditis, new atrial fibrillation, and cardiovascular death within 90 days of COVID-19 diagnosis.
RESULTS: The registry included 6,576 outpatients, of whom 166 (2.5%) had active cancer (mean age 61 ± 16, 53% female). For outpatients with and without active cancer, the 90-day cumulative incidences of thromboembolism after developing COVID-19 were 4.2% and 1.2%, respectively (hazard ratio [HR]: 3.65; 95% confidence interval [CI]: 1.73-7.69,
CONCLUSION: Outpatients with COVID-19 and active cancer demonstrated an increased hazard of thrombotic events compared with outpatients without cancer.
Volume
9
First Page
27132715
Last Page
27132715
ISSN
2512-9465
Published In/Presented At
McGonagle, B., Greason, C., Krishnathasan, D., Scimeca, G., Bejjani, A., Khairani, C. D., Hamade, N., Sato, A., Leyva, H., Campia, U., Davies, J., Porio, N., Assi, A. A., Armero, A., Tristani, A., Ortiz-Rios, M. D., Nauffal, V., Almarzooq, Z., Wei, E., Zuluaga-Sánchez, V., … Piazza, G. (2025). Association between Active Cancer and Risk of Thrombotic and Cardiovascular Outcomes in Outpatients with COVID-19: A CORONA-VTE Network Analysis. TH open : companion journal to thrombosis and haemostasis, 9, a27132715. https://doi.org/10.1055/a-2713-2715
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
41143106
Department(s)
Administration and Leadership
Document Type
Article