Amyloidosis of the upper aerodigestive tract.
Publication/Presentation Date
12-1-2003
Abstract
OBJECTIVES/HYPOTHESIS: To delineate the clinical and pathologic characteristics of upper aerodigestive tract amyloidosis with particular attention to laryngeal amyloidosis.
STUDY DESIGN: Retrospective chart review of patients with amyloidosis of Thomas Jefferson University and its affiliated hospitals.
MATERIAL AND METHODS: The charts of 16 patients with upper aerodigestive tract amyloidosis identified from the databases of the Thomas Jefferson University pathology department were reviewed and included in the study.
RESULTS: Sixteen patients (9 male and 7 female, with an average age of 49.8 years) with upper aerodigestive tract amyloidosis were identified. The most common site of amyloid involvement was the larynx. Consequently, patients most commonly presented with hoarseness (14 of 16). All patients underwent surgical removal of the amyloid deposits. Fourteen patients had primary localized amyloidosis. Two experienced systemic involvement. Seven of the 16 patients developed recurrences requiring further treatment.
CONCLUSIONS: Amyloidosis of the upper aerodigestive tract generally behaves as a benign, localized condition treatable by surgical resection. Regular follow-up with laryngoscopy is indicated for early diagnosis of recurrence, and multiple surgical procedures may be required to control symptoms.
Volume
113
Issue
12
First Page
2095
Last Page
2101
ISSN
0023-852X
Published In/Presented At
Pribitkin, E., Friedman, O., O'Hara, B., Cunnane, M. F., Levi, D., Rosen, M., Keane, W. M., & Sataloff, R. T. (2003). Amyloidosis of the upper aerodigestive tract. The Laryngoscope, 113(12), 2095–2101. https://doi.org/10.1097/00005537-200312000-00007
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
14660909
Department(s)
Administration and Leadership
Document Type
Article