Predictors of consenting to participate in a clinical trial among urban cancer patients.
Publication/Presentation Date
2-1-2023
Abstract
BACKGROUND: Patient participation in clinical trials is influenced by demographic and other individual level characteristics. However, there is less research on the role of geography and neighborhood-level factors on clinical trial participation. This study identifies the demographic, clinical, geographic, and neighborhood predictors of consenting to a clinical trial among cancer patients at a large, urban, NCI-designated cancer center in the Mid-Atlantic region.
METHODS: We used demographic and clinical data from patients diagnosed with cancer between 2015 and 2017. We geocoded patient addresses and calculated driving distance to the cancer center. Additionally, we linked patient data to neighborhood-level educational attainment, social capital and cancer prevalence. Finally, we used generalized linear mixed-effects conditional logistic regression to identify individual and neighborhood-level predictors of consenting to a clinical trial.
RESULTS: Patients with higher odds of consenting to trials were: Non-Hispanic White, aged 50-69, diagnosed with breast, GI, head/neck, hematologic, or certain solid tumor cancers, those with cancers at regional stage, never/former tobacco users, and those with the highest neighborhood social capital index. Patients who lived further from the cancer center had higher odds of consenting to a trial. With every 1-km increase in residential distance, there was a 4% increase in the odds that patients would consent to a trial. Neither of the additional neighborhood-level variables predicted consenting to a clinical trial.
CONCLUSIONS: This study identifies important demographic, patient-level, and geographic factors associated with consenting to cancer clinical trials, and lays the groundwork for future research exploring the role of neighborhood-level factors in clinical trial participation.
Volume
125
First Page
107061
Last Page
107061
ISSN
1559-2030
Published In/Presented At
McIntire, R. K., Keith, S. W., Nowlan, T., Butt, S., Cambareri, K., Callaghan, J., Halstead, T., Chandrasekar, T., Kelly, W. K., & Leader, A. E. (2023). Predictors of consenting to participate in a clinical trial among urban cancer patients. Contemporary clinical trials, 125, 107061. https://doi.org/10.1016/j.cct.2022.107061
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
36567059
Department(s)
Administration and Leadership
Document Type
Article