Intra-Arterial Chemotherapy for Retinoblastoma in Infants ≤10 kg: 74 Treated Eyes with 222 IAC Sessions.
Publication/Presentation Date
7-1-2020
Abstract
BACKGROUND AND PURPOSE: Intra-arterial chemotherapy for retinoblastoma has dramatically altered the natural history of the disease. The remarkable outcomes associated with a high safety profile have pushed the envelope to offer treatment for patients weighing ≤10 kg. The purpose was to determine the efficacy and safety of IAC infusions performed in infants weighing ≤10 kg with intraocular retinoblastoma.
MATERIALS AND METHODS: A retrospective chart review was performed for patients diagnosed with retinoblastoma and managed with intra-arterial chemotherapy.
RESULTS: The total study cohort included 207 retinoblastoma tumors of 207 eyes in 196 consecutive patients who underwent 658 intra-arterial chemotherapy infusions overall. Of these, patient weights were ≤10 kg in 69 (35.2%) and >10 kg in 127 (64.8%) patients. Comparison (≤10 kg versus >10 kg) revealed that the total number of intra-arterial chemotherapy infusions was 222 versus 436. Periprocedural complications were not significantly different (2 [0.9%] versus 2 [0.5%];
CONCLUSIONS: Intra-arterial chemotherapy in patients weighing ≤10 kg is a safe and effective treatment.
Volume
41
Issue
7
First Page
1286
Last Page
1292
ISSN
1936-959X
Published In/Presented At
Sweid, A., Hammoud, B., Weinberg, J. H., Texakalidis, P., Xu, V., Shivashankar, K., Baldassari, M. P., Das, S., Ramesh, S., Tjoumakaris, S., Shields, C. L., Ancona-Lezama, D., Lim, L. S., Dalvin, L. A., & Jabbour, P. (2020). Intra-Arterial Chemotherapy for Retinoblastoma in Infants ≤10 kg: 74 Treated Eyes with 222 IAC Sessions. AJNR. American journal of neuroradiology, 41(7), 1286–1292. https://doi.org/10.3174/ajnr.A6590
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
32586963
Department(s)
Administration and Leadership
Document Type
Article