Impact of smoking on occlusion rates following stereotactic radiosurgery for Spetzler Martin grade I-III brain arteriovenous malformations - A propensity score matched analysis of the MISTA consortium.
Publication/Presentation Date
9-1-2025
Abstract
BACKGROUNDAND OBJECTIVE: The authors compareocclusion rates in grade I-III AVMs in smokers and non-smokers, using propensity score matching (PSM).
METHODS: The authors performed a subgroup analysis of the MISTA consortium, a multicenter registry that includes patients aged 1 to 89 years with AVMs treated between January 2010 and December 2023. Only grade I-III AVMs were included. PSM was used to control confounders. Primary endpoints included angiographic obliteration.
RESULTS: A total of 353 patients with bAVMs, with a median age of 37, were included in this study: 236 were never smokers, and 117 were current or previous smokers. After 1:1 PSM of smokers and non-smokers, 33 matched pairs were obtained. The smokers were more likely to display complete obliteration at last imaging follow-up compared to non-smokers (57.6 % vs. 27.3 %;p < 0.01). The median time to last clinical(p = 0.45)and angiographic(p = 0.33)follow up was not statistically different between the two groups.There were no statistically significant differences between the two matched groups in the incidence of post-SRS edema (p = 0.23), post-treatment rupture (0 %), overall mortality (p = 0.31), and functional status at the last follow-up (p = 0.69).
CONCLUSION: Individuals with a positive history of smoking are more likely to achieve complete obliteration of grades I-III bAVMs following SRS treatment. However, smokers do not differ from non-smokers in terms of the incidence of post-treatment rupture, overall mortality, or functional status at the last follow-up.
Volume
139
First Page
111411
Last Page
111411
ISSN
1532-2653
Published In/Presented At
Sconzo, D., Ramirez-Velandia, F., Muram, S., Enriquez-Marulanda, A., Riordan, C. P., Adeeb, N., Musmar, B., Salim, H. A., Kandregula, S., Dmywtriw, A. A., Abdelsalam, A., Ataoglu, C., Erginoglu, U., Kondziolka, D., Aslan, A., Naamani, K. E., Sheehan, J., Park, M. S., Zeineddine, H. A., Ironside, N., … MISTA Consortiumn (2025). Impact of smoking on occlusion rates following stereotactic radiosurgery for Spetzler Martin grade I-III brain arteriovenous malformations - A propensity score matched analysis of the MISTA consortium. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 139, 111411. https://doi.org/10.1016/j.jocn.2025.111411
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
40578008
Department(s)
Administration and Leadership
Document Type
Article