Effect of Acute Intracranial Stenting in Patients With Successful Reperfusion Following Large-Vessel Occlusion Secondary to Intracranial Atherosclerosis: Secondary Analyses of the RESCUE-ICAS Study.
Publication/Presentation Date
3-1-2026
Abstract
BACKGROUND: The RESCUE-ICAS study (Registry of Emergent Large-Vessel Occlusion due to Intracranial Stenosis) demonstrated that patients undergoing acute stenting of intracranial atherosclerosis with large-vessel occlusion after mechanical thrombectomy had better outcomes than those undergoing mechanical thrombectomy alone. We present 2 secondary analyses of RESCUE-ICAS to evaluate intracranial stenting among patients who achieved successful reperfusion.
METHODS: From a prospective observational cohort of 25 stroke centers (2022-2023), patients with acute intracranial occlusion, National Institutes of Health Stroke Scale score ≥6, and 50% to 99% residual stenosis or occlusion after endovascular thrombectomy were included. In the first analysis, we compared patients with stenting versus those without stenting from among those patients with a final modified Thrombolysis in Cerebral Infarction score of 2B-3. In the second analysis, we compared patients who underwent stenting with those who did not from among the patients with a Thrombolysis in Cerebral Infarction (TICI) score of 2B-3 before stenting. The odds of a favorable 90-day mRS (0-2) and 24-hour MRI infarct volume < 30 mL were assessed using multivariable logistic regression. We also examined the rates of symptomatic ICH and death at 90 days in these cohorts.
RESULTS: Overall, 351 (84.2%) patients had successful reperfusion, with 181 (51.7%) undergoing stenting. More patients who underwent acute stenting achieved an mRS score of 0 to 2 at 90 days (adjusted odds ratio, 1.88;
CONCLUSIONS: Among both the cohort with final successful reperfusion and the cohort with initial successful reperfusion after mechanical thrombectomy alone, intracranial stenting was associated with better long-term clinical and radiographic outcomes, without higher morbidity and mortality.
REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05403593.
Volume
6
Issue
2
First Page
001841
Last Page
001841
ISSN
2694-5746
Published In/Presented At
Nguyen, S., de Havenon, A., Almallouhi, E., Jumaa, M. A., Inoa, V., Capasso, F., Nahhas, M. I., Starke, R. M., Fragata, I., Bender, M. T., Moldovan, K., Yaghi, S., Maier, I., Grossberg, J. A., Jabbour, P. M., Psychogios, M. N., Samaniego, E. A., Burkhardt, J. K., Jankowitz, B. T., Abdalkader, M., … Grandhi, R. (2026). Effect of Acute Intracranial Stenting in Patients With Successful Reperfusion Following Large-Vessel Occlusion Secondary to Intracranial Atherosclerosis: Secondary Analyses of the RESCUE-ICAS Study. Stroke (Hoboken, N.J.), 6(2), e001841. https://doi.org/10.1161/SVIN.125.001841
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
41815302
Department(s)
Administration and Leadership
Document Type
Article