Ticagrelor resistance: a case series and algorithm for management of non-responders.
Publication/Presentation Date
2-1-2022
Abstract
The placement of cervical and intracranial stents requires the administration of antiplatelet drugs to prevent thromboembolic complications. Ticagrelor has emerged as the most widely used alternative in clopidogrel non-responders owing to its potent antiplatelet effects. Because ticagrelor does not require hepatic activation, many neurointerventionalists choose to forgo laboratory testing of platelet inhibition. In rare instances, patients may not achieve adequate platelet inhibition following ticagrelor administration. In this paper we review the mechanism of action of ticagrelor and its use in cerebrovascular procedures. We present two cases of ticagrelor non-responsiveness from two high-volume cerebrovascular centers, discuss their management, and propose an algorithm for managing ticagrelor non-responsiveness.
Volume
14
Issue
2
First Page
179
Last Page
183
ISSN
1759-8486
Published In/Presented At
Laurent, D., Dodd, W. S., Small, C., Gooch, M. R., Ghosh, R., Goutnik, M., Blatt, T., Porche, K., Geh, N., Adamczak, S., Polifka, A. J., Brzezicki, G., Hoh, B., & Chalouhi, N. (2022). Ticagrelor resistance: a case series and algorithm for management of non-responders. Journal of neurointerventional surgery, 14(2), 179–183. https://doi.org/10.1136/neurintsurg-2021-017638
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
34215660
Department(s)
Administration and Leadership
Document Type
Article