A review of multiomics platforms in pituitary adenoma pathogenesis.
Publication/Presentation Date
3-4-2022
Abstract
Pituitary adenomas (PA), or pituitary neuroendocrine tumors (PitNETs), represent 15% of all central nervous system tumors. Classic description of PitNETs solely by hormonal classification has given way to key transcription factors that play a role in the pathology of PitNETs including steroidogenic factor-1 (SF-1), t-box pituitary transcription factor (TPIT), and pituitary transcription factor 1 (PIT-1). Germline mutations in various familial PitNETs are discussed including those in familial isolated pituitary adenoma (FIPA), multiple endocrine neoplasia (MEN), neurofibromatosis 1 (NF1), and Carney complex. Recent advances in next generation sequencing have improved insight into the pathogenesis of PitNETs. A review of key studies in evaluating the genomic analysis of PitNETs was performed. Chromosomal mutations, whole exome sequencing, microRNA genomics, methylomics and transcriptomics were analyzed. Moreover, the multiomic analysis of various genomic panels has helped to better understand PA classification.
Volume
27
Issue
3
First Page
77
Last Page
77
ISSN
2768-6698
Published In/Presented At
Mouchtouris, N., Smit, R. D., Piper, K., Prashant, G., Evans, J. J., & Karsy, M. (2022). A review of multiomics platforms in pituitary adenoma pathogenesis. Frontiers in bioscience (Landmark edition), 27(3), 77. https://doi.org/10.31083/j.fbl2703077
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
35345309
Department(s)
Administration and Leadership
Document Type
Article