Early Findings from the Multicenter RAPID Consortium on Papillary Craniopharyngiomas.
Publication/Presentation Date
8-1-2026
Abstract
BACKGROUND: Craniopharyngiomas are rare parasellar tumors, and papillary craniopharyngiomas (PCPs) represent 8 to 20% of cases.
DESIGN: Interim analysis of retrospective data collected from the Registry of Adenomas of the Pituitary and Related Disorders (RAPID).
SETTING: Fourteen U.S.-based academic skull base centers between 2011 and 2023.
PARTICIPANTS: Patients with PCPs.
MAIN OUTCOME MEASURES: Demographic, imaging, surgical, and outcome variables.
RESULTS: Ninety-nine patients with PCPs were included. The mean age was 51.8 ± 14.7, and 57.6% were male. Most tumors showed mixed cystic/solid components (67.5%), were transinfundibular (50.0%), and were treated with an endoscopic endonasal approach (74.5%), with 51.1% demonstrating gross total resection (GTR). Pituitary stalk was preserved in 51.9%. Permanent arginine vasopressin deficiency was seen in 67.1% and was associated with pituitary stalk sacrifice (
CONCLUSIONS: RAPID consortium enabled the largest real-world clinical information dataset for PCPs. Early findings support that GTR and stalk preservation are important to outcomes. Iterative analysis and discussion of data led to the generation of a framework for future studies to fully leverage the capabilities of multicenter registries.
Volume
87
Issue
4
First Page
406
Last Page
413
ISSN
2193-6331
Published In/Presented At
Catalino, M. P., Pham, D., Rennert, R. C., Couldwell, W. T., Evans, J. J., Callopy, C., Kim, W., Pacione, D., Suryadevara, C. M., Kim, A., Silverstein, J., Chicoine, M., Gardner, P. A., Barkhoudarian, G., Miranda, J. C. F., Benjamin, C., Kshettry, V. R., Zada, G., Gompel, J. J. V., Palit, S. R., … Karsy, M. (2025). Early Findings from the Multicenter RAPID Consortium on Papillary Craniopharyngiomas. Journal of neurological surgery. Part B, Skull base, 87(4), 406–413. https://doi.org/10.1055/a-2646-2339
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
42404182
Department(s)
Administration and Leadership
Document Type
Article