Multiple coexistent dysraphic pathologies.
Publication/Presentation Date
6-1-2003
Abstract
INTRODUCTION: Four distinct dysraphic anomalies were observed in a single child. While combinations of such anomalies are well recognised, quadruple dysraphic pathology, nevertheless, is extremely uncommon. To our knowledge, no previous cases have been reported in the literature.
CASE REPORT: We present the management of a child with a concurrent segmental meningocele, a type-1 split cord malformation (SCM) associated with hemivertebrae, lipomyelomeningoceles in each hemicord of the SCM and a terminal myelocystocele, and we review the literature on potential mechanisms of dysmorphogenesis.
DISCUSSION: Existing embryologic hypotheses for the dysraphic spectrum lack experimental evidence and studies in animal models. This case challenges the existing hypotheses and illustrates our incomplete understanding of human terminal spinal cord embryogenesis. Further studies on the morphogenetic basis for these anomalies are required.
Volume
19
Issue
5-6
First Page
376
Last Page
379
ISSN
0256-7040
Published In/Presented At
Solanki, G. A., Evans, J., Copp, A., & Thompson, D. N. (2003). Multiple coexistent dysraphic pathologies. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 19(5-6), 376–379. https://doi.org/10.1007/s00381-003-0728-y
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
12692674
Department(s)
Administration and Leadership
Document Type
Article