DTCs/CTCs in breast cancer: five decades later.
Publication/Presentation Date
1-1-2012
Abstract
Since circulating tumor cells were first reported in 1955, the field has seen major advances in their detection and has established their prognostic impact. Here we review the current evidence for the prognostic and predictive value of circulating tumor cells in metastatic breast cancer. We then evaluate the role of CTCs and DTCs in early stage breast cancer. The weight of the evidence supports the role of CTCs and DTCs as prognostic indicators, however their role in therapy prediction remains unclear. Ongoing trials may provide answers and newer detection methods which improve sensitivity and specificity may have greater impact. At this point, the data does not support incorporation into clinical practice for early breast cancer patients.
Volume
195
First Page
217
Last Page
225
ISSN
0080-0015
Published In/Presented At
Alsamarai, S., Abu-Khalaf, M. M., & Harris, L. N. (2012). DTCs/CTCs in breast cancer: five decades later. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 195, 217–225. https://doi.org/10.1007/978-3-642-28160-0_20
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
22527509
Department(s)
Administration and Leadership
Document Type
Article