L-arginine levels are diminished in adult acute vaso-occlusive sickle cell crisis in the emergency department.

Authors

• Bernard L Lopez
• Allyson A Kreshak
• Claudia R Morris
• Linda Davis-Moon
• Samir K Ballas
• Xin-Liang Ma

Publication/Presentation Date

2-1-2003

Abstract

Paediatric studies have demonstrated that l-arginine (l-arg), the precursor to nitric oxide, is diminished in vaso-occlusive crisis (VOC). This study aimed to determine whether l-arginine levels are altered in adult VOC in the emergency department. Plasma l-arg and nitric oxide metabolite (NOx) levels were obtained in adult VOC patients presenting to the emergency department. Fifty patients had significantly low plasma l-arg (29.78 micromol/l +/- 11.21, P < 0.05 vs steady-state control = 41.16 micromol/l +/- 5.04) and significantly low plasma NOx (12.33 micromol/l +/- 10.28, P < 0.05 vs steady-state control = 25.2 +/- 2.6 micro mol/l). Neither l-arg nor NOx levels could predict VOC clinical course.

Volume

120

Issue

3

First Page

532

Last Page

534

ISSN

0007-1048

Published In/Presented At

Lopez, B. L., Kreshak, A. A., Morris, C. R., Davis-Moon, L., Ballas, S. K., & Ma, X. L. (2003). L-arginine levels are diminished in adult acute vaso-occlusive sickle cell crisis in the emergency department. British journal of haematology, 120(3), 532–534. https://doi.org/10.1046/j.1365-2141.2003.04109.x

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

12580975

Department(s)

Administration and Leadership

Document Type

Article