Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function.
Publication/Presentation Date
1-7-2022
Abstract
BACKGROUND: Patients with acute myocardial infarction suffer systemic metabolic dysfunction via incompletely understood mechanisms. Adipocytes play critical role in metabolic homeostasis. The impact of acute myocardial infarction upon adipocyte function is unclear. Small extracellular vesicles (sEVs) critically contribute to organ-organ communication. Whether and how small extracellular vesicle mediate post-MI cardiomyocyte/adipocyte communication remain unknown.
METHODS: Plasma sEVs were isolated from sham control (Pla-sEV
RESULTS: An unbiased approach identified EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3) as a novel downstream target of miR-27a. Adipocyte EDEM3 deficiency phenocopied multiple pathological alterations caused by Myo-sEV
CONCLUSIONS: We demonstrate for the first time that MI/R causes significant adipocyte ER stress and endocrine dysfunction by releasing miR-23-27-24 cluster-enriched small extracellular vesicle. Targeting small extracellular vesicle-mediated cardiomyocyte-adipocyte pathological communication may be of therapeutic potential to prevent metabolic dysfunction after MI/R.
Volume
130
Issue
1
First Page
48
Last Page
66
ISSN
1524-4571
Published In/Presented At
Gan, L., Liu, D., Xie, D., Bond Lau, W., Liu, J., Christopher, T. A., Lopez, B., Liu, L., Hu, H., Yao, P., He, Y., Gao, E., Koch, W. J., Zhao, J., Ma, X. L., Cao, Y., & Wang, Y. (2022). Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte Function. Circulation research, 130(1), 48–66. https://doi.org/10.1161/CIRCRESAHA.121.320157
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
34763521
Department(s)
Administration and Leadership
Document Type
Article