Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress.

Authors

• Zheyi Yan
• Rui Guo
• Lu Gan
• Wayne Bond Lau
• Xiaoming Cao
• Jianli Zhao
• Xinliang Ma
• Theodore A Christopher
• Bernard L Lopez
• Yajing Wang

Publication/Presentation Date

10-15-2018

Abstract

Withaferin A (WFA), a withanolide derived from medicinal plant Withania somnifera, possesses anti-tumorigenic and immunomodulatory activities against various cancer cells. However, the role of WFA in myocardial ischemia reperfusion (MI/R) injury remains unclear. In the present study, we determined whether WFA may regulate cardiac ischemia reperfusion injury and elucidate the underlying mechanisms. We demonstrated that WFA enhanced H9c2 cells survival ability against simulated ischemia/reperfusion (SI/R) or hydrogen peroxide (H

Volume

211

First Page

91

Last Page

101

ISSN

1879-0631

Published In/Presented At

Yan, Z., Guo, R., Gan, L., Lau, W. B., Cao, X., Zhao, J., Ma, X., Christopher, T. A., Lopez, B. L., & Wang, Y. (2018). Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress. Life sciences, 211, 91–101. https://doi.org/10.1016/j.lfs.2018.09.020

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

30213729

Department(s)

Administration and Leadership

Document Type

Article