Long Noncoding RNA LINC00092 Acts in Cancer-Associated Fibroblasts to Drive Glycolysis and Progression of Ovarian Cancer.

Authors

• Linjie Zhao
• Gaili Ji
• Xiaobing Le
• Chenlu Wang
• Lian Xu
• Min Feng
• Yaguang Zhang
• Huiliang Yang
• Yu Xuan
• Yanfei Yang
• Lingzi Lei
• Qilian Yang
• Wayne Bond Lau
• Bonnie Lau
• Yi Chen
• Xiangbing Deng
• Shaohua Yao
• Tao Yi
• Xia Zhao
• Yuquan Wei
• Shengtao Zhou

Publication/Presentation Date

3-15-2017

Abstract

The majority of patients with epithelial ovarian cancer are diagnosed at a late stage when the peritoneal metastases exist; however, there is little knowledge of the metastatic process in this disease setting. In this study, we report the identification of the long noncoding RNA LINC00092 as a nodal driver of metastatic progression mediated by cancer-associated fibroblasts (CAF). Prometastatic properties of CAFs

Volume

77

Issue

6

First Page

1369

Last Page

1382

ISSN

1538-7445

Published In/Presented At

Zhao, L., Ji, G., Le, X., Wang, C., Xu, L., Feng, M., Zhang, Y., Yang, H., Xuan, Y., Yang, Y., Lei, L., Yang, Q., Lau, W. B., Lau, B., Chen, Y., Deng, X., Yao, S., Yi, T., Zhao, X., Wei, Y., … Zhou, S. (2017). Long Noncoding RNA LINC00092 Acts in Cancer-Associated Fibroblasts to Drive Glycolysis and Progression of Ovarian Cancer. Cancer research, 77(6), 1369–1382. https://doi.org/10.1158/0008-5472.CAN-16-1615

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

28087599

Department(s)

Administration and Leadership

Document Type

Article