LncRNAs: the bridge linking RNA and colorectal cancer.
Publication/Presentation Date
2-14-2017
Abstract
Long noncoding RNAs (lncRNAs) are transcribed by genomic regions (exceeding 200 nucleotides in length) that do not encode proteins. While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, lncRNAs control pleiotropic cancer phenotypes through interactions with other cellular molecules including DNA, protein, and RNA. Recent studies have demonstrated that dysregulation of lncRNAs is influential in proliferation, angiogenesis, metastasis, invasion, apoptosis, stemness, and genome instability in colorectal cancer (CRC), with consequent clinical implications. In this review, we explicate the roles of different lncRNAs in CRC, and the potential implications for their clinical application.
Volume
8
Issue
7
First Page
12517
Last Page
12532
ISSN
1949-2553
Published In/Presented At
Yang, Y., Zhao, L., Lei, L., Lau, W. B., Lau, B., Yang, Q., Le, X., Yang, H., Wang, C., Luo, Z., Xuan, Y., Chen, Y., Deng, X., Xu, L., Feng, M., Yi, T., Zhao, X., Wei, Y., & Zhou, S. (2017). LncRNAs: the bridge linking RNA and colorectal cancer. Oncotarget, 8(7), 12517–12532. https://doi.org/10.18632/oncotarget.13573
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
27888635
Department(s)
Administration and Leadership
Document Type
Article